MLL antibody (10R-2084)

Mouse monoclonal MLL antibody

Synonyms Monoclonal MLL antibody, Anti-MLL antibody, Zinc finger protein HRX antibody, ALL 1 antibody, ALL 1 antibody, MLL antibody, ALL-1 antibody, Lysine N-methyltransferase 2A antibody, Lysine N-methyltransferase 2A antibody, Zinc finger protein HRX antibody, HRX antibody, Anti MLL antibody, ALL-1 antibody, Myeloid/lymphoid leukemia antibody, Myeloid/lymphoid leukemia antibody, Trithorax-like protein antibody, HRX antibody, Trithorax-like protein antibody
Cross Reactivity Human
Applications ELISA, IHC, WB
Immunogen MLL antibody was raised in Mouse using a purified recombinant fragment of MLL(aa3751-3968) expressed in E. coli as the immunogen.

Images

Immunohistochemical staining using MLL antibody (10R-2084)

Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and esophagus cancer (right), showing nuclear weak staining with DAB staining using MLL antibody.

Specifications

Host Mouse
Clone 10F8D7
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance MLL contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes.

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Images

  • Immunohistochemical staining using MLL antibody (10R-2084) | Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and esophagus cancer (right), showing nuclear weak staining with DAB staining using MLL antibody.
  • Western Blot analysis using MLL antibody (10R-2084) | Western Blot showing MLL antibody used against truncated MLL recombinant protein (1) and truncated GFP-MLL (aa3714-3969) transfected Cos7 cell lysate (2).

Availability: In stock

Price: $345.00
Size: 100 ul
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