MORF4L2 protein (His tag) (80R-1745)
Purified recombinant Human MORF4L2 protein
|Synonyms||MRGX protein, MORF4L2, MORFL2-4, MORFL2 protein, KIAA0026 protein, MORFL2-4 protein, Mortality factor 4-like protein 2 protein, MORFL2 4 protein, MORFL2 4|
Coomassie Blue stained SDS-PAGE of MORF4L2 protein (His tag) (80R-1745)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-288 amino acids: MGSSHHHHHH SSGLVPRGSH MSSRKQGSQP RGQQSAEEEN FKKPTRSNMQ RSKMRGASSG KKTAGPQQKN LEPALPGRWG GRSAENPPSG SVRKTRKNKQ KTPGNGDGGS TSEAPQPPRK KRARADPTVE SEEAFKNRME VKVKIPEELK PWLVEDWDLV TRQKQLFQLP AKKNVDAILE EYANCKKSQG NVDNKEYAVN EVVAGIKEYF NVMLGTQLLY KFERPQYAEI LLAHPDAPMS QVYGAPHLLR LFVRIGAMLA YTPLDEKSLA LLLGYLHDFL KYLAKNSASL FTASDYKVAS AEYHRKAL|
|Purity||> 90% pure|
|Molecular Weight||34.4 kDa (308aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||MORF4L2 is a member of the mortality factor (MORF) family of transcriptional regulator that is involved in cell growth, regulation and senescence. This protein localizes to the nucleus, and it has a protein kinase C phosphorylation site as well as a tyrosine phosphorylation site. It interacts with the Rb tumor suppressor through its helix-loop-helix and leucine zipper regions. It also has histone deacetylase activity and can either repress or promote the activity of the B-Myb promoter depending on the tissue. Recombinant human MORF4L2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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