MPZL1 protein (His tag) (80R-2931)
Purified recombinant NSMCE1 protein (His tag)
|Synonyms||Myelin protein zero-like 1 isoform b protein, MPZL1b protein, PZR protein, PZR1b protein, PZRa protein, PZRb protein, MPZL 1 protein, MPZL-1 protein|
SDS-PAGE analysis of MPZL1 protein (His Tag) (80R-2931)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||38-162 aa: MGSSHHHHHH SSGLVPRGSH MGSLEVYTPK EIFVANGTQG KLTCKFKSTS TTGGLTSVSW SFQPEGADTT VSFFHYSQGQ VYLGNYPPFK DRISWAGDLD KKDASINIEN MQFIHNGTYI CDVKNPPDIV VQPGHIRLYV VEKENLPV|
|Purity||> 90% pure|
|Molecular Weight||16.1 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT|
Storage & Safety
|Storage||Store at 4 deg C for up to 2 weeks. For long term storage, aliquot and store at -20 deg C to -70 deg C. Avoid repeated freeze/thaw cycles|
|Biological Significance||MPZL1 is a cell surface receptor, which is involved in signal transduction processes. This protein recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. It is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.|
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