MRE11 antibody (10R-8639)

Mouse monoclonal MRE11 antibody

Synonyms Monoclonal MRE11 antibody, Anti-MRE11 antibody, MRE11A antibody, MRE11 meiotic recombination 11 homolog A (S. cerevisiae) antibody, ATLD antibody, AT-like disease antibody, BOS_14243 antibody, DNA recombination and repair protein antibody, double-strand break repair protein MRE11 antibody, double-strand break repair protein MRE11A antibody, endo/exonuclease Mre11 antibody, HNGS1 antibody, meiotic recombination 11 homolog 1 antibody, meiotic recombination 11 homolog A antibody, meiotic recombination 11 homolog A (S. cerevisiae) antibody, meiotic recombination 11-like protein antibody, mmMRE11A antibody, Mre11 antibody, mre11-a antibody, MRE11B antibody, MRE11 homolog 1 antibody, MRE11 homolog A antibody, MRE11 meiotic recombination 11 homolog A antibody, putative nuclease Mre11 antibody, RP23-149D5.3 antibody
Cross Reactivity Human
Applications WB
Immunogen MRE11 antibody was raised in Mouse using a recombinant human protein purified from E.coli (His-MRE11) as the immunogen

Images

Western Blot analysis using MRE11 antibody (10R-8639)

Specifications

Host Mouse
Clone 44B12
Isotype IgG2b kappa
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance MRE11 is a component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

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Images

  • Western Blot analysis using MRE11 antibody (10R-8639) |

Availability: In stock

Price: $295.00
Size: 100 ul
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