MSH6 antibody (10R-2166)
Mouse monoclonal MSH6 antibody
|Synonyms||Monoclonal MSH6 antibody, Anti-MSH6 antibody, Muts Homolog 6 antibody, GTBP antibody, MSH 6, MSH-6 antibody, HNPCC5 antibody, MSH-6, MSH 6 antibody, HSAP antibody, MSH6|
|Immunogen||MSH6 antibody was raised in Mouse using a purified recombinant fragment of MSH6 expressed in E. coli as the immunogen.|
Western Blot analysis using MSH6 antibody (10R-2166)
Western Blot showing MSH6 antibody used against truncated MSH6 recombinant protein.
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Defects in MSH6 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world. MSH6 is central to mismatch DNA repair.|
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