MuSK antibody (10R-2058)

Mouse monoclonal MuSK antibody

Synonyms Monoclonal MuSK antibody, Anti-MuSK antibody, MuSK antibody, Anti MuSK antibody, Muscle Specific Kinase antibody, Muscle Specific Kinase antibody
Cross Reactivity Human
Applications ELISA, IF, IHC
Immunogen MuSK antibody was raised in Mouse using purified recombinant extracellular fragment of human MuSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line as the immunogen.

Images

Immunofluorescent staining using (MuSK antibody)

Confocal immunofluorescence analysis of HEK293 cells trasfected with extracellular MUSK (aa24-209)-hIgGFc using MUSK antibody (green). Blue: DRAQ5 fluorescent DNA dye.

Specifications

Host Mouse
Clone 10A4
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IF: 1:200-1:1000, IHC: 1:200-1:1000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance MuSK is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin, his protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK.

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Images

  • Immunofluorescent staining using  (MuSK antibody) | Confocal immunofluorescence analysis of HEK293 cells trasfected with extracellular MUSK (aa24-209)-hIgGFc using MUSK antibody (green). Blue: DRAQ5 fluorescent DNA dye.
  • Immunohistochemical staining using MuSK antibody (10R-2058) | Immunohistochemical analysis of paraffin-embedded human lung cancer (A), muscles (B) and breast cancer (C) using MUSK antibody with DAB staining.

Availability: In stock

Price: $345.00
Size: 100 ul
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