Myeloperoxidase antibody (20R-MR012)

Rabbit polyclonal Myeloperoxidase antibody

Synonyms Polyclonal Myeloperoxidase antibody, Anti-Myeloperoxidase antibody, Myeloperoxidase antibody, MPO antibody, 89 kDa myeloperoxidase antibody, 84 kDa myeloperoxidase antibody, Myeloperoxidase light chain antibodyMyeloperoxidase heavy chain
Specificity Human myeloperoxidase
Cross Reactivity To be determined by end-user
Applications ELISA, IP, WB
Immunogen Myeloperoxidase antibody was raised in rabbit using myeloperoxidase from human Leukocytes as the immunogen.


Host Rabbit
Isotype IgG2a
Method of Purification Myeloperoxidase antibody was purified by delipidation and defibrination.
Form & Buffer Lyophilized from 0.02M K3PO4, pH 7.2, with 0.15M NaCl, and 0.01%NaN3.

Usage & Assay Information

Usage Recommendations ELISA: 1:200,000, IP: 1:100, WB: 1:5,000

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

General Information

Biological Significance Human myeloperoxidase (MPO) is a dimeric protein composed of two heavy subunits (53 kDa) and two light subunits (15 kDa). Each MPO molecule contains two prosthetic porphyrins which play an important role in the catalytic cycle. Molecular weights for MPO isoforms from pools of normal human samples range from 114,000 to 140,000 daltons reflecting a heterogeneous mixture of isoforms when assayed under non-reducing conditions of SDS-PAGE. Often MPO from a single donor will yield a homogenous preparation reflecting a single isoform. The carbohydrate component of MPO, consisting of mannose, glucose and N-acetylglucosamine residues is 2.5%. MPO is inhibited by azide and other compounds. MPO is stored in primary granules of neutrophils and serves as a bactericidal agent in that MPO catalyzes the production of hypochlorous acid (HOCl), a powerful oxidant. HOCl is derived from chloride ion (Cl-) and hydrogen peroxide (H2O2). In a number of inflammatory situations, MPO is released into the extracellular matrix where its measurement can be used as an indication of neutrophil activation.

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