NABP1 protein (His tag) (80R-3486)

Purified recombinant NABP1 protein (His tag)

Synonyms OBFC2A protein, SOSS-B2 protein, SSB2 protein, NABP 1 protein, NABP-1 protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

Coomassie blue stained SDS-PAGE of NABP1 protein (His tag) (80R-3486)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 1-204 aa: MGSSHHHHHH SSGLVPRGSH MGSMNRVNDP LIFIRDIKPG LKNLNVVFIV LEIGRVTKTK DGHEVRSCKV ADKTGSITIS VWDEIGGLIQ PGDIIRLTRG YASMWKGCLT LYTGRGGELQ KIGEFCMVYS EVPNFSEPNP DYRGQQNKGA QSEQKNNSMN SNMGTGTFGP VGNGVHTGPE SREHQFSHAG RSNGRGLINP QLQGTASNQT VMTTISNGRD PRRAFKR
Expression System E.coli
Purity > 95% pure
Method of Purification NABP1 protein was purified by using conventional chromatography techniques
Molecular Weight 24.8 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in liquid form in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT
Concentration 500 ug/ml

Storage & Safety

Storage Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.

General Information

Biological Significance Nucleic acid binding protein 1, also known as NABP1, is component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, the protein acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. This protein is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

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Images

  • Coomassie blue stained SDS-PAGE of NABP1 protein (His tag) (80R-3486) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: $275.00
Size: 100 ug
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