NBC1 protein (His tag) (80R-1132)
Purified recombinant Human NBC1 protein
|Synonyms||Na+HCO3- cotransporter 4 protein, Solute carrier family 4 sodium bicarbonate cotransporter member 4 protein, kNBC 1 protein, NBC-1 protein, Sodium bicarbonate cotransporter kidney protein, Solute carrier family 4 member 4 protein, NBC-1, sodium bicarbonate cotransporter member 4 protein, PNBC protein, NBC1 protein, SLC4A5 protein, isoform2 protein, Electrogenic sodium bicarbonate cotransporter 1 protein, HNBC1 protein, Electrogenic sodium bicarbonate cotransporter 1 protein, NBC 1, NBC1, Solute carrier family 4 sodium bicarbonate cotransporter member 5., NBC 1 protein, hhNMC protein, Sodium bicarbonate cotransporter pancreas protein, NBC2 protein, Na(+)/HCO3(-) cotransporter protein, NBCE1 protein, NBC 1 protein, NBCE1 protein, NBC 2 protein, NBCE 1 protein, Nbc4 protein, SLC4A4 protein, HNBC 1 protein, isoform2 DKFZp781H1314 protein|
Coomassie Blue stained SDS-PAGE of NBC1 protein (His tag) (80R-1132)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-424 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSTE NVEGKPSNLG ERGRARSSTF LRVVQPMFNH SIFTSAVSPA AERIRFILGE EDDSPAPPQL FTELDELLAV DGQEMEWKET ARWIKFEEKV EQGGERWSKP HVATLSLHSL FELRTCMEKG SIMLDREASS LPQLVEMIVD HQIETGLLKP ELKDKVTYTL LRKHRHQTKK SNLRSLADIG KTVSSASRMF TNPDNGSPAM THRNLTSSSL NDISDKPEKD QLKNKFMKKL PRDAEASNVL VGEVDFLDTP FIAFVRLQQA VMLGALTEVP VPTRFLFILL GPKGKAKSYH EIGRAIATLM SDEVFHDIAY KAKDRHDLIA GIDEFLDEVI VLPPGEWDPA IRIEPPKSLP SSDKRKNMYS GGENVQMNGD TPHDGGHGGG GHGDCEELQR TGRFCGGLIK DIKRKAPFFA SDFYDALNIQ|
|Purity||> 90% pure|
|Molecular Weight||51.5 kDa (460aa)|
|Form & Buffer||In 20 mM Tris-HCl buffer, pH 7.5, containing 0.5mM DTT, 0.1mM PMSF, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. NBC1 has been identified as a key player for regulation of intracellular pH in several cell types. NBC1 Isoform 2 is specifically expressed in kidney at the level of proximal tubules. Recombinant human NBC1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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