NCBP2 protein (His tag) (80R-1509)
Purified recombinant Human NCBP2 protein
|Synonyms||NCBP 2, CBC2 protein, NIP1 protein, NCBP 2 protein, NCBP-2, CBP20 protein, NCBP-2 protein, PIG55, NCBP2, Nuclear cap-binding protein subunit 2 protein|
Coomassie Blue stained SDS-PAGE of NCBP2 protein (His tag) (80R-1509)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-156 amino acids: MGSSHHHHHH SSGLVPRGSH MSGGLLKALR SDSYVELSQY RDQHFRGDNE EQEKLLKKSC TLYVGNLSFY TTEEQIYELF SKSGDIKKII MGLDKMKKTA CGFCFVEYYS RADAENAMRY INGTRLDDRI IRTDWDAGFK EGRQYGRGRS GGQVRDEYRQ DYDAGRGGYG KLAQNQ|
|Purity||> 95% pure|
|Molecular Weight||20.1 kDa (176aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCl and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||NCBP2, also known as CBC2, is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. This protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Recombinant human NCBP2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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