New Infectious Disease Antibodies

Launched August 2016 - New mouse monoclonal antibodies against popular infectious disease targets

  • Antibodies can all be used as either solid phase or conjugate antibodies in sandwich immunoassays such as ELISA and Lateral Flow.
  • Supplied as an IgG1 mouse monoclonal in PBS with sodium azide added as preservative.
  • Supplied as 1 mg at $365.
  • Free samples and bulk quotes can be negotiated on request.
  • Contact us at antibodies@fitzgerald-fii.com for further information or click on the links below to see technical specifications.

Rotavirus antibody (10-2722) Clone # M86696

Rotavirus is a genus of double-stranded RNA viruses in the family Reoviridae. There are eight species of this virus, referred to as A, B, C, D, E, F, G and H. Rotavirus A, the most common species, causes more than 90% of rotavirus infections in humans. It causes viral gastroenteritis particularly in children. Rotavirus is transmitted by the fecal-oral route, via contact with contaminated hands, surfaces and objects, and possibly by the respiratory route.

Rotavirus is the leading cause of gastroenteritis in children and infants, and is highly contagious. Symptoms include nausea, diarrhoea, vomiting, and abdominal pain.

Helicobacter pylori antibody (10-2723) Clone # M86697

Helicobacter pylori is a gram-negative, microaerophilic bacterium found usually in the stomach. It was first identified by Australian scientists Barry Marshall and Robin Warren in 1982, who isolated from a patient suffering with chronic gastritis and gastric ulcers. It has since been linked to the development of duodenal ulcers and stomach cancer. However, it is found in about two-thirds of the world's population who mainly are asymptomatic, and so it is thought to play a role in the natural stomach ecology.            

H. pylori infection usually happens during childhood and is a common cause of peptic ulcers of the stomach.  H. pylori infections are usually treated with two varieties of antibiotics at once, to help prevent the bacteria from developing a resistance to one particular antibiotic, and with an acid supressing drug such as Bismuth subsalicylate.

Clostridium difficile antibody (10-2724) Clone # M86698

Clostridia are anaerobic motile bacteria, ubiquitous in nature, and especially prevalent in soil. Under the microscope, they appear as long, irregular (often drumstick- or spindle-shaped) cells with a bulge at their terminal ends. All Clostridium difficile strains appear to produce the cell wall-associated enzyme glutamate dehydrogenase antigen (GDH). GDH appears to be highly conserved among C. difficile ribotypes and most likely independent from PaLoc structure. GDH detection is a high sensitivity test for the presence of Clostridium difficile, after which it should be confirmed by detection of the bacteria itself.

Clostridium difficile colitis or pseudomembranous colitis is colitis resulting from infection with Clostridium difficile. C. difficile infection can range from mild to life-threatening. Symptoms of mild cases include watery diarrhea, with abdominal pain or tenderness.

Campylobacter antibody (10-2725) Clone # M86699

Campylobacter antibody (10-2726) Clone # M86700

Campylobacter is a Gram-negative, microaerophilic, oxidase-positive, catalase-positive, nonfermentative bacteria. Most Campylobacter species cause disease in humans and other animals with the bacterium's main reservoir being poultry. However, humans can contract the disease from contaminated food.

Campylobacteriosis is the illness caused by Campylobacter species. Campylobacter jejuni is the predominant species associated with human illness, other species being Campylobacter coli and Campylobacter lari. Symptoms include diarrhoea, cramping, abdominal pain, and fever within 2 to 5 days after exposure to the organism.

Giardia intestinalis antibody (10-2727) Clone # M86701

Giardia intestinalis antibody (10-2728) Clone # M86702

Giardia intestinalis is a flagellated protozoan parasite that colonizes and reproduces in the small intestine, causing giardiasis. The parasite attaches to the epithelium by a ventral adhesive disc, and reproduces via binary fission. Giardia infection can occur through ingestion of dormant microbial cysts in contaminated water, food, or by the fecal-oral route.

Giardiasis is the most frequently diagnosed intestinal parasitic disease in the United States and among travelers with chronic diarrhea. Signs and symptoms may vary and can last for 1 to 2 weeks or longer. In some cases, people infected with Giardia have no symptoms.

Calprotectin antibody (10-2729) Clone # M86703

Calprotectin is a 24 kDa dimer of calcium binding proteins S100A8 and S100A9 and the complex accounts for up to 60% of the soluble protein content of the neutrophil cytosol. Fecal calpronectin is used as a biomarker for inflammatory bowel diseases, coeliac disease, infectious colitis, necrotizing enterocolitis, intestinal cystic fibrosis and colorectal cancer.

Elevated faecal calprotectin indicates the migration of neutrophils to the intestinal mucosa, which occurs during intestinal inflammation, including inflammation caused by inflammatory bowel disease.