Nitrotyrosine antibody (10R-8507)

Mouse monoclonal Nitrotyrosine antibody

Synonyms Monoclonal Nitrotyrosine antibody, Anti-Nitrotyrosine antibody, 3-Nitrotyrosine antibody, Nitrotyrosine antibody antibody
Cross Reactivity All
Applications ELISA, IP, WB
Immunogen Nitrotyrosine antibody was raised in Mouse using Peroxynitrate treated BSA as the immunogen

Images

Western Blot analysis using Nitrotyrosine antibody (10R-8507)

Specifications

Host Mouse
Clone 1F1
Isotype IgG1 kappa
Method of Purification Nitrotyrosine antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:10000, IP: 3 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Nitrotyrosine has been implicated in the pathogenesis of many inflammatory, infectious and degenerative human diseases such as Alzheimer?s disease, atherosclerosis, asthma and a variety of conditions mediated by endothelial injury. Oxidative stress has been indicated as a mechanism of secondary neuronal injury in traumatic brain injury. Nitrotyrosine in the cerebrospinal fluid may be an in vivo marker of oxidative nitric oxide damage. Several pathologies of the cardiovascular system are also associated with an augmented production of nitric oxide and/or superoxide-derived oxidants that lead to nitroxidative stress. The high contents of iron (heme) in certain tissues such as heart and vascular smooth muscle cells could serve as a biological base for iron toxicity on free radical-mediated tissue damage, including formation of nitrotyrosine.

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Images

  • Western Blot analysis using Nitrotyrosine antibody (10R-8507) |

Availability: In stock

Price: $295.00
Size: 100 ul
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