Nitrotyrosine antibody (20R-2915)

Rabbit polyclonal Nitrotyrosine antibody

Synonyms Polyclonal Nitrotyrosine antibody, Anti-Nitrotyrosine antibody, 3-Nitrotyrosine antibody, Nitrotyrosine antibody- antibody
Cross Reactivity Human
Applications WB
Immunogen Nitrotyrosine antibody was raised in Rabbit using a synthetic target peptide as the immunogen


Western Blot analysis using Nitrotyrosine antibody (20R-2915)


Host Rabbit
Isotype IgG
Method of Purification Nitrotyrosine antibody was purified by Protein A affinity chromatography
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Nitrotyrosine is a relatively stable product formed from various reaction pathways. Perhaps most notable is the reaction of peroxynitrite (formed from Superoxide and nitric oxide radicals) with tyrosine. As a strong oxidant and nitrating agent, peroxynitrite mediates tyrosine nitration reactions on proteins resulting in inactivation of certain housekeeping enzymes (e.g. alpha1-antiproteinase) as well as endogenous antioxidant enzymes such as catalase and SOD. Nitrotyrosine has been identified as an indicator of cell damage and inflammation, as well as of the production of NO. It is believed that measuring the concentration of nitrotyrosine will serve as a marker for damage caused by NO in the cell. Nitrotyrosine has been implicated in the pathogenesis of several inflammatory, infectious and degenerative human diseases, such as Alzheimer?s disease, amyotrophic lateral sclerosis (ALS), asthma, atherosclerosis and a variety of conditions precipitated by endothelial injury.

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  • Western Blot analysis using Nitrotyrosine antibody (20R-2915) |

Availability: In stock

Price: $295.00
Size: 100 ul
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