NMNAT1 antibody (10R-1183)

Mouse monoclonal NMNAT1 antibody

Synonyms Monoclonal NMNAT1 antibody, Anti-NMNAT1 antibody, NMNAT antibody, NMNAT 1, NMNAT-1, PNAT1 antibody, NMNAT-1 antibody, Nicotinamide nucleotide adenylyltransferase 1 antibody, NMNAT1, NMNAT 1 antibody
Specificity Human
Cross Reactivity To be determined by end-user.
Applications ELISA, WB
Immunogen NMNAT1 antibody was raised in mouse using recombinant human NMNAT1 (1-279aa) purified from E. Coli as the immunogen.

Images

Western blot analysis using NMNAT1 antibody (10R-1183)

Figure is annotated with cell line lysates which were probed by the antibody

Specifications

Host Mouse
Clone AT4A2
Isotype IgG2b kappa
Source Anti-human NMNAT1 antibody, clone AT4A2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human NMNAT1 protein.
Method of Purification NMNAT1 antibody was purified by protein-G affinity chromatography
Form & Buffer Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1:500-1:1,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Nicotinamide mononucleotide adenylyltransferase 1 is an enzyme that in humans is encoded by the NMNAT1 gene. It is an essential enzyme because it catalyzes the final step of NAD+ biosynthesis. There are three isoforms in humans that exhibit tissue- and organelle-specific expression. NMNAT-1 is localized exclusively in the nucleus, whereas NMNAT-2 and NMNAT-3 are found in the Golgi and mitochondria, respectively. NMNAT1 constitute a nuclear NAD+ salvage pathway which regulates the functions of NAD+-dependent enzymes such as the protein deacetylase SIRT1. NMNAT1 protects neurons from neuronal activity induced degeneration.

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Images

  • Western blot analysis using NMNAT1 antibody (10R-1183) | Figure is annotated with cell line lysates which were probed by the antibody

Availability: In stock

Price: $265.00
Size: 100 ul
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