NNT1 protein (30R-AN041)

Purified recombinant Human NNT1 protein

Synonyms NNT-1 protein, NNT-1 protein, Novel Neurtrophin-1/B-Cell Stimulating Factor-3 protein, Cardiotrophin-like cytokine protein, NNT 1, NNT 1 protein, NNT1, NNT-1
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of NNT1 protein corresponding to amino acids MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF.
Expression System E.coli
Purity > 98% pure
Molecular Weight 22.4 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance NNT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, NNT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member beta (LIFR-beta) and induces tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss and B cell hyperplasia associated with increased in serum IgG and IgM.

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Availability: In stock

Price: $225.00
Size: 10 ug
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