NPM antibody (10R-2450)

Mouse monoclonal NPM antibody

Synonyms Monoclonal Nucleolar Protein NO38 antibody, Anti Nucleolar Protein NO38 antibody, NPM antibody, Anti Nucleolar Protein NO38 antibody, Nucleolar phosphoprotein B23 antibody, NPM antibody, Nucleolar Protein NO38 antibody, Numatrin antibody, B23 antibody, Numatrin antibody, Nucleolar phosphoprotein B23 antibody, Nucleophosmin antibody, B23 antibody, Nucleophosmin antibody
Specificity Xenopus laevis oocytes
Cross Reactivity Frog, Chicken, Newt
Applications IF, IP, WB
Immunogen Nucleolar Protein NO38 antibody was raised in mouse using Nucleolar fraction prepared from Xenopus laevis oocytes as the immunogen.

Specifications

Host Mouse
Clone No-63
Isotype IgG2a
Form & Buffer Supplied in liquid form, contains 0.09% NaN3

Usage & Assay Information

Usage Recommendations IHC: 1:300 - 1:500, WB: 1000-2000

Storage & Safety

Storage Store at 2-8 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene. NPM1 is associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It is involved in the biogenesis of ribosomes and may assist small basic proteins in their transport to the nucleolus. Its regulation through SUMOylation (by SENP3 and SENP5) is another facet of the proteins's regulation and cellular functions.

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