NQO2 protein (His tag) (80R-1288)
Purified recombinant Human NQO2 protein
|Synonyms||Quinone protein, Ribosyldihydronicotinamide dehydrogenase Ox2 protein, NAD(P)H menadione oxidoreductase 2 dioxin inducible protein, QR2 protein, EC 126.96.36.199 protein, NQO 2 protein, NQO 2 protein, NRH:quinone oxidoreductase 2 protein, QR2 protein, NMOR2 protein, NQO-2, NAD(P)H dehydrogenase quinone 2 protein, NQO 2, DIA6 protein, OTTHUMP00000015948 protein, NRH dehydrogenase protein, Ribosyldihydronicotinamide dehydrogenase., OTTHUMP00000015953 protein, NQO-2 protein, DHQV protein, OTTHUMP00000015949 protein, NQO2, Quinone reductase 2 protein, Ox 2 protein, MGC94180 protein, NAD(P)H menadione oxidoreductase 1 dioxin inducible 2 protein|
Coomassie Blue stained SDS-PAGE of NQO2 protein (His tag) (80R-1288)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-231 amino acids: MGSSHHHHHH SSGLVPRGSH MAGKKVLIVY AHQEPKSFNG SLKNVAVDEL SRQGCTVTVS DLYAMNFEPR ATDKDITGTL SNPEVFNYGV ETHEAYKQRS LASDITDEQK KVREADLVIF QFPLYWFSVP AILKGWMDRV LCQGFAFDIP GFYDSGLLQG KLALLSVTTG GTAEMYTKTG VNGDSRYFLW PLQHGTLHFC GFKVLAPQIS FAPEIASEEE RKGMVAAWSQ RLQTIWKEEP IPCTAHWHFG Q|
|Purity||> 95% pure|
|Molecular Weight||28.1 kDa (251aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||NQO2 is a member of the NAD(P)H dehydrogenase (quinone) . The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. It is flavoproteins that catalyze the metabolic detoxification of quinones and their derivatives to hydroquinones. This detoxification process protects cells against quinone-induced oxidative stress, cytotoxicity and mutagenicity. Recombinant human NQO2 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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