NUDT5 protein (His tag) (80R-1395)
Purified recombinant Human NUDT5 protein
|Synonyms||NUDT-5, NUDT 5, YSA1 protein, hYSAH1 protein, NUDT5, NUDT 5, YSA1H protein, NUDT-5 protein, HSPC115 protein, NUDT-5 protein, ADP-sugar pyrophosphatase protein, NUDT 5 protein, Nudix motif 5 protein|
Coomassie Blue stained SDS-PAGE of NUDT5 protein (His tag) (80R-1395)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-219 amino acids: MGSSHHHHHH SSGLVPRGSH MESQEPTESS QNGKQYIISE ELISEGKWVK LEKTTYMDPT GKTRTWESVK RTTRKEQTAD GVAVIPVLQR TLHYECIVLV KQFRPPMGGY CIEFPAGLID DGETPEAAAL RELEEETGYK GDIAECSPAV CMDPGLSNCT IHIVTVTING DDAENARPKP KPGDGEFVEV ISLPKNDLLQ RLDALVAEEH LTVDARVYSY ALALKHANAK PFEVPFLKF|
|Purity||> 85% pure|
|Molecular Weight||26.5 kDa (239aa), confirmed by MALDI-TOF (Real molecular weight on SDS-PAGE will appear higher)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, 1mM DTT and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||NUDT5 is a member of the nudix hydrolase family which eliminate toxic nucleotide derivatives from the cell. NUDT5 hydrolyzes ADP-ribose and ADP-mannose in the presence of magnesium, and also hydrolyzes other nucleotide sugars with low activity such as ADP-glucose and diadenosine diphosphate. As a nudix hydrolase, NUDT5 contains a central nudix motif and functions to eliminate toxic nucleotide metabolites from the cell while maintaining the levels of signaling nucleotides. NUDT5 is widely expressed but is most abundant in liver as a homodimer. Recombinant human NUDT5 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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