OAS1 antibody (70R-10568)
Affinity purified rabbit polyclonal OAS1 antibody
|Synonyms||Polyclonal OAS1 antibody, Anti-OAS1 antibody, 40/46kDa antibody, OIASI antibody, OIAS antibody, OAS 1, 5'-oligoadenylate synthetase 1, OAS-1, OAS-1 antibody, 2', OAS1, IFI-4 antibody, OAS 1 antibody|
|Immunogen||OAS1 antibody was raised in rabbit using the C terminal of OAS1 as the immunogen|
|Assay Information||OAS1 Blocking Peptide, catalog no. 33R-2289, is also available for use as a blocking control in assays to test for specificity of this OAS1 antibody|
Western Blot analysis using OAS1 antibody (70R-10568)
OAS1 antibody (70R-10568) used at 0.2-1 ug/ml to detect target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||OAS1 is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. It is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Mutations in this gene have been associated with host susceptibility to viral infection.|
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