Osteoprotegerin/TNFRSF11B protein (His tag) (80R-1112)
Purified recombinant Human Osteoprotegerin/TNFRSF11B protein
|Synonyms||TNFRSF11B protein, TR 1 protein, OPG protein, Osteoprotegerin/TNFRSFB-11, Osteoclastogenesis inhibitory factor protein, OCIF protein, TR1 protein, Osteoprotegerin/TNFRSFB 11 protein, Osteoprotegerin/TNFRSFB-11 protein, Osteoprotegerin/TNFRSFB 11, member 11b MGC29565 protein, Tumor Necrosis Factor Receptor Superfamily Member 11b., Osteoprotegerin/TNFRSF11B, Tumor necrosis factor receptor superfamily protein, TNFRSF 11B protein|
Coomassie Blue stained SDS-PAGE of Osteoprotegerin/TNFRSF11B protein (His tag) (80R-1112)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||22-401 amino acids: ADPETFPPKY LHYDEETSHQ LLCDKCPPGT YLKQHCTAKW KTVCAPCPDH YYTDSWHTSD ECLYCSPVCK ELQYVKQECN RTHNRVCECK EGRYLEIEFC LKHRSCPPGF GVVQAGTPER NTVCKRCPDG FFSNETSSKA PCRKHTNCSV FGLLLTQKGN ATHDNICSGN SESTQKCGID VTLCEEAFFR FAVPTKFTPN WLSVLVDNLP GTKVNAESVE RIKRQHSSQE QTFQLLKLWK HQNKDQDIVK KIIQDIDLCE NSVQRHIGHA NLTFEQLRSL MESLPGKKVG AEDIEKTIKA CKPSDQILKL LSLWRIKNGD QDTLKGLMHA LKHSKTYHFP KTVTQSLKKT IRFLHSFTMY KLYQKLFLEM IGNQVQSVKI SCLSGRLVPR GSHHHHHH|
|Purity||> 85% pure|
|Molecular Weight||45.6 kDa (398 aa) (On SDS-PAGE under denatured condition, apparent molecular weight of glycosylated rhOPG protein will be appeared at approximately 55 kDa)|
|Form & Buffer||Supplied as a liquid in PBS, pH 7.4, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF)-related family, is referred to as TNFRSF11B and part of the OPG/receptor activator of NF-?B ligand (RANKL)/receptor activator of NF-kB (RANK) triad. This cytokine that lacks any apparent cell-association motifs and exists as a soluble secreted protein, network regulates the differentiation and activation of osteoclasts and hence the critical balance between bone formation (osteoblasts) and bone resorption (osteoclasts). Recombinant human osteoprotegerin protein, fused to His-tag at C-terminus, was expressed in Hi-5 cell using baculovirus expression system and purified by using conventional chromatography techniques|
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