Otubain 1 protein (His tag) (80R-1172)
Purified recombinant Human Otubain 1 protein
|Synonyms||Otubain -1 protein, OTU domain containing ubiquitin aldehyde binding protein 1 protein, Ubiquitin specific processing protease OTUB1 protein, Otubain 1 protein, Otubain -1, Ubiquitin thioesterase OTUB1., Otubain 1 protein, Ubiquitin thioesterase Otubain 1 Deubiquitinating enzyme OTUB1 protein, OTU1 protein, Otubain 1, OTB1 protein, Otubain 1|
Coomassie Blue stained SDS-PAGE of Otubain 1 protein (His tag) (80R-1172)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-271 amino acids: MGSSHHHHHH SSGLVPRGSH MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK SKEDLVSQGF TEFTIEDFHN TFMDLIEQVE KQTSVADLLA SFNDQSTSDY LVVYLRLLTS GYLQRESKFF EHFIEGGRTV KEFCQQEVEP MCKESDHIHI IALAQALSVS IQVEYMDRGE GGTTNPHIFP EGSEPKVYLL YRPGHYDILY K|
|Purity||> 95% pure|
|Molecular Weight||33.4 kDa (291aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris buffer, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Otubain 1, also known as OTUB1, is a member of the OUT (ovarian tumor) superfamily of predicted cysteine proteases and inhibits cytokine gene transcription in the immune system via its interaction with a ubiquitin protease and E3 ubiquitin ligase. This protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function of polyubiquitin chain growth. Recombinant OTUB1 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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