OX40 Ligand protein (30R-AO007)

Purified recombinant Human OX40 Ligand protein

Synonyms OX40 Ligand, OX40L protein, OX Ligand-40, CD252 protein, OX Ligand-40 protein, OX Ligand 40 protein, Gp34 protein, TNFSF4 protein, OX Ligand 40
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Expression System Hi-5 cells
Purity > 97% pure
Molecular Weight 15.5-25 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 30-100 ng/ml. Note: Results may vary with PBMC donors.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL2, IL3, and IFN.

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Availability: In stock

Price: $225.00
Size: 10 ug
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