p16 INK4 alpha protein (30R-AP044)

Purified recombinant Human p16 INK4 alpha protein

Synonyms p INK4 alpha 16 protein, p INK4 alpha-16, p16-INK4 protein, Cyclin-dependent kinase inhibitor 2A protein, MTS-1 protein, p16INK4A protein, Cyclin-dependent kinase 4 inhibitor A protein, p16 INK-4 alpha protein, p16 INK4 alpha, p INK4 alpha-16 protein, p INK4 alpha 16, CDK4I protein, Multiple tumor suppressor 1 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of p16 INK4 alpha protein corresponding to amino acids MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD.
Expression System E.coli
Purity > 95% pure
Molecular Weight 16.5 kDa
Form & Buffer Supplied as a lyophilized powder.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance p16-INK4a is a nuclear protein that regulates the cell cycle by inhibiting cyclin dependent kinase-4 (CDK4) and CDK6. p16-INK4a inhibits CDK activity by binding to the CDK molecules in a manner that interferes with their ability to interact with cyclin D. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of p16-INK4a steadily increases with age and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the p16-INK4a gene is frequently found in melanomas as well as in certain other types of cancer.

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Availability: In stock

Price: $225.00
Size: 20 ug
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