P4HB antibody (10R-3119)

Mouse monoclonal P4HB antibody

Synonyms Monoclonal P4HB antibody, Anti-P4HB antibody, PHB 4, PHB-4 antibody, P4HB, PO4HB antibody, PO4DB antibody, PHB-4, ERBA2L antibody, PHB 4 antibody, PDI antibody, PHDB antibody, Procollagen-Proline 2-Oxoglutarate 4-Dioxygenase Beta Polypeptide antibody, GIT antibody, PROHB antibody, PDIA1 antibody, DSI antibody
Cross Reactivity Human
Applications User optimized

Images

Western Blot analysis using P4HB antibody (10R-3119)

Western Blot showing P4HB antibody used at a concentration of 2.5 ug/ml against THP-1 Cell Lysate

Specifications

Host Mouse
Clone 3 G5
Isotype IgG
Form & Buffer Supplied in lyophilized form with PBS buffer. Reconstitute in 100 ul of distilled water.
Concentration 1 mg/ml

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -200 deg C for long term storage. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance P4HB is the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.

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Images

  • Western Blot analysis using P4HB antibody (10R-3119) | Western Blot showing P4HB antibody used at a concentration of 2.5 ug/ml against THP-1 Cell Lysate

Availability: In stock

Price: $300.00
Size: 100 ug
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