p53 antibody (20R-2904)

Rabbit polyclonal p53 antibody

Synonyms Polyclonal p53 antibody, Anti-p53 antibody, TP53 antibody, tumor protein p53 antibody, antigen NY-CO-13 antibody, BCC7 antibody, BOS_18908 antibody, brp53 antibody, cellular tumor antigen p53 antibody, drp53 antibody, EGK_08142 antibody, etID22686.5 antibody, fb40d06 antibody, LFS1 antibody, Li-Fraumeni syndrome antibody, p53 antibody, p53 tumor suppressor antibody, p53 tumor suppressor phosphoprotein antibody, phosphoprotein p53 antibody, transformation related protein 53 antibody, transformation-related protein 53 antibody, trp53 antibody, tumor protein 53 antibody, tumor protein p53 (Li-Fraumeni syndrome) antibody, tumor suppressing protein antibody, tumor suppressor homolog p53 antibody, Tumor suppressor p53 antibody, tumor suppressor protein antibody, tumor suppressor protein p53 antibody, tumor suppressor TP53 antibody, tumor supressor p53 antibody, Xp53 antibody
Cross Reactivity Human, Mouse, Rat
Applications WB
Immunogen p53 antibody was raised in Rabbit using a synthetic target peptide as the immunogen

Images

Western Blot analysis using p53 antibody (20R-2904)

Specifications

Host Rabbit
Isotype IgG
Method of Purification p53 antibody was purified by affinity chromatography
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance p53 is a transcription factor that regulates the cell cycle and hence functions as a tumor suppressor. p53 has been described as "the guardian of the genome", referring to its role in conserving stability by preventing genome mutation. p53 has many anti-cancer mechanisms: activating DNA repair proteins when DNA has sustained damage, holding the cell cycle at the G1/S regulation point on DNA damage recognition, initiating apoptosis if the DNA damage proves to be irrepairable. Human p53 is 393 amino acids long and has three domains: 1) N-terminal transcription-activation domain (TAD), which activates transcription factors. 2) central DNA-binding core domain (DBD) 3) C-terminal homo-oligomerisation domain (OD); tetramerization greatly increases the activity of p53 in vivo. Mutations that deactivate p53 in cancer usually occur in the DBD and most of these mutations destroy the ability of the protein to bind to its target DNA sequences

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Images

  • Western Blot analysis using p53 antibody (20R-2904) |

Availability: In stock

Price: $285.00
Size: 100 ul
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