p97 ATPase antibody (10R-2431)

Mouse monoclonal p97 ATPase antibody

Synonyms Monoclonal p97 ATPase antibody, Anti p97 ATPase antibody, p97 ATPase, p ATPase-97 antibody, p ATPase-97, p ATPase 97 antibody, p ATPase 97
Cross Reactivity To be determined by the end user
Applications WB
Immunogen p97 ATPase antibody was raised in mouse using 15S Mg2+ ATPase complex purified from Xenopus laevis ovary as the immunogen.

Specifications

Host Mouse
Clone 58.13.3
Isotype IgG1
Form & Buffer Supplied in liquid form, dilute with 0.15 M PBS with 0.1% BSA and 0.1% sodium azide before use

Usage & Assay Information

Usage Recommendations WB: 1:5 - 1:10

Storage & Safety

Storage Store at 2-8 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance p97 ATPase / VCP (also described as valosin-containing protein) is implicated in homotypic membrane fusion events and is related to the N-ethyl maleimide-sensitive fusion protein NSF/Sec18p. The antibody reacts with the p97 subunit of 15S Mg2+-ATPase. p97/VCP is involved in ubiquitin-proteasome dependent protein degradation processes and involvement was also found e.g. in the formation of neuronal inclusion bodies in neuro-degenerative diseseases (e.g. Parkinson’s disease).

References
Add a Paper

Robert Ernst, Britta Mueller, Hidde L. Ploegh, Christian Schlieker

The Otubain YOD1 Is a Deubiquitinating Enzyme that Associates with p97 to Facilitate Protein Dislocation from the ER

Molecular Cell

Volume: 36 Issue: 1 Page: 28-38 DOI: 10.1016/j.molcel.2009.09.016

Xiangning Jianga, Renatta Knoxa, Praneeti Pathipatia, Donna Ferriero

Developmental localization of NMDA receptors, Src and MAP kinases in mouse brain

Neuroscience Letters

Volume: 503 Issue: 3 Page: 215-219 DOI: 10.1016/j.neulet.2011.08.039

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