PAIP2 protein (His tag) (80R-1215)
Purified recombinant Human PAIP2 protein
|Synonyms||PABP- interacting protein 2 protein, Poly(A)-binding protein-interacting protein 2 poly(A) binding protein interacting protein 2., PAIP 2, PAIP-2 protein, PAIP2, PAIP 2 protein, HSPC218 protein, PAIP2A protein, PAIP-2|
Coomassie Blue stained SDS-PAGE of PAIP2 protein (His tag) (80R-1215)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-127 amino acids: MGSSHHHHHH SSGLVPRGSH MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE LWEEEFIERC FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISDGS SLEDLVVKSN LNPNAKEFVP GVKYGNI|
|Purity||> 90% pure|
|Molecular Weight||17.1 kDa (147aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||PAIP2, also known as Poly(A)-binding protein-interacting protein 2, acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. It displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. Recombinant PAIP2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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