pan Cytokeratin antibody (10R-2060)

Mouse monoclonal pan Cytokeratin antibody

Synonyms Monoclonal pan Cytokeratin antibody, Anti-pan Cytokeratin antibody
Cross Reactivity Human
Applications ELISA, IF, IHC
Immunogen pan Cytokeratin antibody was raised in Mouse using a purified recombinant fragment of Cytokeratin 5 expressed in E. coli as the immunogen.

Images

Immunofluorescent staining using (Cytokeratin Pan antibody)

Confocal immunofluorescence analysis of methanol-fixed Eca-109 cells using Cytokeratin (Pan) antibody (green), showing cytoplasmic localization. Blue: DRAQ5 fluorescent DNA dye.

Specifications

Host Mouse
Clone 7H8
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IF: 1:200-1:1000, IHC: 1:200-1:1000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors.

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Images

  • Immunofluorescent staining using  (Cytokeratin Pan antibody) | Confocal immunofluorescence analysis of methanol-fixed Eca-109 cells using Cytokeratin (Pan) antibody (green), showing cytoplasmic localization. Blue: DRAQ5 fluorescent DNA dye.
  • Immunohistochemical staining using Cytokeratin Pan antibody (10R-2060) | Immunohistochemical analysis of paraffin-embedded human lung squamous cell carcinoma (A),normal hepatocyte (B), colon adenocacinoma, normal stomach tissue (D), showing cytoplasmic and membrane localization using CK antibody with DAB staining.

Availability: In stock

Price: $345.00
Size: 100 ul
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