PARP1 antibody (70R-1092)

Rabbit polyclonal PARP1 antibody

Synonyms Polyclonal PARP1 antibody, Anti-PARP1 antibody, PARP 1, PARP-1, Poly (ADP-ribose) polymerase 1 antibody, PARP-1 antibody, PARP 1 antibody, PARP1, Adp-Ribose Polymerase 1 antibody
Cross Reactivity Human,Mouse,Rat,Dog
Applications WB
Immunogen PARP1 antibody was raised using a synthetic peptide corresponding to a region with amino acids ISRLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVIDTSLLYN
Assay Information PARP1 Blocking Peptide, catalog no. 33R-4164, is also available for use as a blocking control in assays to test for specificity of this PARP1 antibody

Images

Western Blot analysis using PARP1 antibody (70R-1092)

PARP1 antibody (70R-1092) used at 5 ug/ml to detect target protein.

Specifications

Host Rabbit
Method of Purification Total IgG Protein A purified
Molecular Weight 113 kDa (MW of target protein)
Form & Buffer Lyophilized powder. Add 100ul distilled water for a 1mg/ml concentration of PARP1 antibody in PBS
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 5 ug/ml

Storage & Safety

Storage Store at 2-8 deg C for short periods. For longer periods of storage, store at -20 deg C. Avoid repeat freeze-thaw cycles.

General Information

Biological Significance PARP1 encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. PARP1 can be cleaved resulting in fragements of 29 and 85 kDa.

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Images

  • Western Blot analysis using PARP1 antibody (70R-1092) | PARP1 antibody (70R-1092) used at 5 ug/ml to detect target protein.

Availability: In stock

Price: $275.00
Size: 100 ug
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