PBEF1 antibody (10R-2129)
Mouse monoclonal PBEF1 antibody
|Synonyms||Monoclonal PBEF1 antibody, Anti-PBEF1 antibody, NAMPT antibody, Pre-B-Cell Colony Enhancing Factor 1 antibody, PBEF antibody, DKFZP666B131 antibody, MGC117256 antibody, PBEF-1, PBEF 1 antibody, PBEF 1, PBEF1, 1110035O14Rik antibody, PBEF-1 antibody|
|Immunogen||PBEF1 antibody was raised in Mouse using a purified recombinant fragment of PBEF1(aa338-479) expressed in E. coli as the immunogen.|
Western Blot analysis using PBEF1 antibody (10R-2129)
Western Blot showing PBEF1 antibody used against truncated PBEF1-His recombinant protein (1) and full-length GFP-PBEF1 (aa1-491) transfected COS7 cell lysate (2).
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||PBEF1 catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.|
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