PCBD1 protein (His tag) (80R-1461)
Purified recombinant Human PCBD1 protein
|Synonyms||PCBD1, PHS, PCBD 1, PCD protein, DCOH protein, PCBD-1 protein, Pterin-4-alpha-carbinolamine dehydratase protein, PCBD protein, PCBD-1, PCBD 1 protein|
Coomassie Blue stained SDS-PAGE of PCBD1 protein (His tag) (80R-1461)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-104 amino acids: MGSSHHHHHH SSGLVPRGSH MAGKAHRLSA EERDQLLPNL RAVGWNELEG RDAIFKQFHF KDFNRAFGFM TRVALQAEKL DHHPEWFNVY NKVHITLSTH ECAGLSERDI NLASFIEQVA VSMT|
|Purity||> 95% pure|
|Molecular Weight||14.1 kDa (124aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Pterin-4-alpha-carbinolamine dehydratase precursor, also known as PCBD1, is a component of the phenylalanine hydroxylase (PAH) system and participates in tetrahydrobiopterin biosynthesis. A deficiency of this enzyme leads to hyperphenylalaninemia. The enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1). Recombinant human PCBD1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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