Immunohistochemical staining using PCBP2 antibody (70R-1378)
PCBP2 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Alveolar cells (arrows) in Human Lung. Magnification is at 400X
PCBP2 antibody
Immunohistochemical staining using PCBP2 antibody (70R-1378)
PCBP2 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Alveolar cells (arrows) in Human Lung. Magnification is at 400X
Western Blot analysis using PCBP2 antibody (70R-1378)
PCBP2 antibody (70R-1378) used at 1.25 ug/ml to detect target protein.
Specifications
Host
Rabbit
Method of Purification
Total IgG Protein A purified
Molecular Weight
40 kDa (MW of target protein)
Form & Buffer
Lyophilized powder. Add 100ul distilled water for a 1mg/ml concentration of PCBP2 antibody in PBS
Store at 2-8 deg C for short periods. For longer periods of storage, store at -20 deg C. Avoid repeat freeze-thaw cycles.
General Information
Biological Significance
PCBP2 appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. This protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.