Perforin antibody (PE) (61R-P116aPE)

Mouse monoclonal Perforin antibody (PE)

Synonyms Monoclonal Perforin antibody, Anti-Perforin antibody
Specificity Human
Cross Reactivity To be determined by end-user
Applications FC, IHC
Immunogen Perforin antibody (PE) was raised in mouse using purified granules from human YT lymphoma cell line as the immunogen.

Specifications

Host Mouse
Clone delta G9
Isotype IgG2b kappa
Method of Purification Perforin antibody (PE) was purified by Protein A chromatography.
Tag/Conjugate PE
Form & Buffer 50mM Na3PO4, pH 7.5, with 500mM KCL, 150mM NaCl, 15% Glycerol, 0.2% BSA, and 0.04% NaN3.
Concentration 0.5 mg/ml

Usage & Assay Information

Usage Recommendations FC: 10 ug/ml

Storage & Safety

Storage Store at 4 deg C. DO NOT FREEZE. Keep away from light.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

General Information

Biological Significance Human perforin (cytolysin) is believed to be one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Perforin expression is constitutive on NK cells, but increases in resting CD8+ cytotoxic cells upon activation.

References
Add a Paper

Jacques Banchereau, Sandra Zurawski, LuAnn Thompson-Snipes, Jean-Philippe Blanck, Sandra Clayton, Adiel Munk, Yanying Cao, Zhiqing Wang, Sunaina Khandelwal, Jiancheng Hu, William H. McCoy IV, Karolina A. Palucka, Yoram Reiter, Daved H. Fremont, Gerard Zurawski, Marco Colonna, Andrey S. Shaw, Eynav Klechevsky

Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming

PNAS

Volume: 109 Issue: 46 Page: 18885-18890 DOI: 10.1073/pnas.1205785109

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Availability: In stock

Price: $624.75
Size: 120 tests
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