Peroxiredoxin SO3 antibody (10R-8413)

Mouse monoclonal Peroxiredoxin SO3 antibody

Synonyms Monoclonal Peroxiredoxin SO3 antibody, Anti-Peroxiredoxin SO3 antibody, PRDX1 antibody, peroxiredoxin 1 antibody, BOS_3608 antibody, CH211-284B7.7 antibody, EGK_00700 antibody, Hbp23 antibody, heme-binding 23 kDa protein antibody, macrophage 23 kDa stress protein antibody, macrophage 23kDa stress protein antibody, macrophage 23 Kd stress protein antibody, macrophase stress protein 22kDa antibody, macrophase stress protein 23 kd antibody, MSP23 antibody, natural killer cell-enhancing factor A antibody, natural killer-enhancing factor A antibody, nkefa antibody, NKEF-A antibody, OSF3 antibody, OSF-3 antibody, osteoblast specific factor 3 antibody, osteoblast-specific factor 3 antibody, PAG antibody, paga antibody, pagb antibody, Peroxiredoxin-1 antibody, PrdxI antibody, proliferation-associated gene A antibody, proliferation-associated gene protein antibody, prx1 antibody, prx-1 antibody, PrxI antibody, RP23-177C18.2 antibody, Tdpx2 antibody, TDX2 antibody, thioredoxin dependent peroxide reductase 2 antibody, thioredoxin-dependent peroxide reductase 2 antibody, Thioredoxin peroxidase 2 antibody, thioredoxin peroxidase II antibody, TPX-2 antibody, TPxA antibody, Trx dependent peroxide reductase 2 antibody
Cross Reactivity Human
Applications WB
Immunogen Peroxiredoxin SO3 antibody was raised in Mouse using a sulfonylated peptide(KLH coupled) corresponding to the active site sequence common to mammalian Prx I to IV as the immunogen

Images

Western Blot analysis using Peroxiredoxin SO3 antibody (10R-8413)

Specifications

Host Mouse
Clone 10A1
Isotype IgG1 kappa
Method of Purification Peroxiredoxin SO3 antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:100-500

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Peroxiredoxin, an antioxidant enzyme detoxifying reactive oxygen species and has a cysteine at their active site. Prx enzymes modulate various receptor signaling pathways and protect cells from oxidatively induced death. Prx I to IV have two conserved Cys residues corresponding to Cys51 and Cys172 of mammalian Prx I. The active site cysteine (Cys51) is oxidized to cysteine sulfenic acid (Cys51-SOH) when a peroxide is reduced. Because Cys51-SOH is unstable, it forms a disulfide with Cys172-SH which comes from other subunit of the homodimer. The disulfide is then reduced back to the Prx active thiol form by the thioredoxin-thioredoxin reductase system. However, the formation of the disulfide is a slow process. Thus under oxidative stress condition, the sulfenic intermediate (Cys51-SOH) can be easily overoxidized to cysteine sulfinic acid (Cys-SO2H) or cysteine sulfonic acid (Cys-SO3H) before it is able to form a disulfide. Recent studies suggest that overoxidized Prx can be reduced back to the active form during recovery after oxidative stress.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Images

  • Western Blot analysis using Peroxiredoxin SO3 antibody (10R-8413) |

Availability: In stock

Price: $295.00
Size: 100 ul
OR
Shipping
View Our Distributors