Phospho-Rb (SER780) antibody (10R-P122a)

Mouse monoclonal Phospho-Rb (SER780) antibody

Synonyms Monoclonal Phospho-Rb (SER780) antibody, Anti-Phospho-Rb (SER780) antibody
Specificity Human
Cross Reactivity To be determined by end-user
Applications WB
Immunogen Phospho-Rb (SER780) antibody was raised in mouse using synthetic human phosoho-RB(ser780) peptide, TRPPTLS(PO3)PIPHIP, which corresponds to amino acids 774-786 of human pRB as the immunogen.

Specifications

Host Mouse
Clone 2C4
Isotype IgG1
Form & Buffer Supplied as a lyophilized powder. Reconstitute in 100 ul of distilled water.

Usage & Assay Information

Usage Recommendations WB: 1 ug/ml

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance Cyclin-dependent kinases (Cdks) play important roles in the regulation of the cell cycle. RB protein (pRB) is phosphorylated by cyclin D-Cdk4/Cdk6 and cyclin A/cyclin E-Cdk2 during the G1/S transition. This phosphorylation causes the inactivation of the growth inhibitory functions of pRB. pRB undergo phosphorylation and attendant functional inactivation, the cell proceed into late G1. Cyclin D-Cdk4 specifically phosphorylates Ser780 in pRB, while cyclin E-Cdk2 and cyclin A-Cdk2 does not.

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Availability: In stock

Price: $525.00
Size: 100 ug
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