PML antibody (10R-1742)

Mouse monoclonal PML antibody

Synonyms Monoclonal PML antibody, Anti-PML antibody, PP8675 antibody, Anti PML antibody, MYL antibody, Promyelocytic leukemia antibody, TRIM19 antibody, TRIM19 antibody, RNF71 antibody, PML antibody, Promyelocytic leukemia antibody, PP8675 antibody, MYL antibody, RNF71 antibody
Specificity Human PML
Cross Reactivity Human. Other species not studied
Applications Dot Blot, ICC
Immunogen PML antibody was raised in mouse using recombinant Human Promyelocytic Leukemia

Images

Western blot analysis using PML antibody (10R-1742)

Specifications

Host Mouse
Clone 880C3a
Isotype IgG1
Method of Purification PML antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer PML antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

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Images

  • Western blot analysis using PML antibody (10R-1742) |

Availability: In stock

Price: $190.00
Size: 50 ug
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