PPP1R1B antibody (70R-14956)

Rabbit polyclonal PPP1R1B antibody

Synonyms Polyclonal PPP1R1B antibody, Anti-PPP1R1B antibody, PPP1R 1B antibody, PPP1R-1B antibody, PPP1R1B, DARPP32 antibody, Phospho-DARPP-32 antibody, Protein phosphatase 1 regulatory subunit 1B antibody, PPP1R1B antibody, Dopamine- and cAMP-regulated neuronal phosphoprotein antibody
Applications IHC, WB

Images

Immunofluorescent staining using PPP1R1B antibody (70R-14956)

Immunochemical staining of cultured CD1 mouse striatal cells showing specific labeling of DARPP32 in green and TUJ1 in red

Specifications

Host Rabbit
Method of Purification PPP1R1B antibody was purified by affinity chromatography
Form & Buffer Supplied in liquid form in 10 mM HEPES buffer (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:1000, IHC: 1:250

General Information

Biological Significance Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons that also express dopamine D1 receptors. The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions.

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Images

  • Immunofluorescent staining using PPP1R1B antibody (70R-14956) | Immunochemical staining of cultured CD1 mouse striatal cells showing specific labeling of DARPP32 in green and TUJ1 in red
  • Western Blot analysis using PPP1R1B antibody (70R-14956) | Western blot of rat hippocampal lysate showing specific immunolabeling of ~32k DARPP protein

Availability: In stock

Price: $335.00
Size: 100 ul
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