PPP1R3B protein (His tag) (80R-3036)
Purified recombinant PPP1R3B protein (His tag)
|Synonyms||Protein phosphatase 1 regulatory subunit 3B protein, GL protein, PPP1R4 protein, PTG protein, PPP1R 3B protein, PPP1R-3B protein|
SDS-PAGE analysis of PPP1R3B protein (His tag) (80R-3036)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-285 aa: MGSSHHHHHH SSGLVPRGSH MGSMMAVDIE YRYNCMAPSL RQERFAFKIS PKPSKPLRPC IQLSSKNEAS GMVAPAVQEK KVKKRVSFAD NQGLALTMVK VFSEFDDPLD MPFNITELLD NIVSLTTAES ESFVLDFSQP SADYLDFRNR LQADHVCLEN CVLKDKAIAG TVKVQNLAFE KTVKIRMTFD TWKSYTDFPC QYVKDTYAGS DRDTFSFDIS LPEKIQSYER MEFAVYYECN GQTYWDSNRG KNYRIIRAEL KSTQGMTKPH SGPDLGISFD QFGSPRCSYG LFPEWPSYLG YEKLGPYY|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol|
Storage & Safety
|Storage||Store at 4 deg C for short term storage, for long term storage aliquot and store at -20 deg C or -70 deg C, avoid repeated freeze thaw cycles.|
|Biological Significance||TFPI is a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The protein inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. TFPI is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.|
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