PRAK antibody (10R-8478)

Mouse monoclonal PRAK antibody

Synonyms Monoclonal PRAK antibody, Anti-PRAK antibody, MAPKAPK5 antibody, mitogen-activated protein kinase-activated protein kinase 5 antibody, BOS_16625 antibody, EGK_04198 antibody, MAPK-activated protein kinase 5 antibody, MAPKAP-K5 antibody, MAPKAPK-5 antibody, MAPKAP kinase 5 antibody, MAP kinase-activated protein kinase 5 antibody, MK5 antibody, MK-5 antibody, p38-regulated/activated protein kinase antibody, prak antibody, TGas086c06.1 antibody
Cross Reactivity Human, Mouse, Rat
Applications ELISA, WB
Immunogen PRAK antibody was raised in Mouse using a recombinant human protein purified from E.coli (His-PRAK) as the immunogen

Images

Western Blot analysis using PRAK antibody (10R-8478)

Specifications

Host Mouse
Clone 13H5
Isotype IgG1 kappa
Method of Purification PRAK antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:5000 -10000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance PRAK is a 471 amino acid protein with 20-30% sequence identity to the known MAP kinase-regulated protein kinases RSK1/2/3, MNK1/2 and MAPKAPK2/3. The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. There are at least six protein kinases that can be regulated by p38alpha and/or p38beta. These downstream kinases of p38s include MAPK-activated protein kinase 2 (MAPKAPK2 or MK2), MAPKAPK3, MAPK-interacting kinase 1 (MNK1), MNK2, p38-activated/regulated protein kinase (PRAK or MAPKAPK5), and mitogen- and stress-activated protein kinase (MSK). PRAK can be activated in response to cellular stress and proinflammatory cytokines. T182 within the activation loop of PRAK has been determined to be the regulatory phosphorylation site. PRAK has been reoprted to be essential for ras-induced senescence and tumor suppression. PRAK mediates senescence upon activation by p38 in response to oncogenic ras.

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Images

  • Western Blot analysis using PRAK antibody (10R-8478) |

Availability: In stock

Price: $295.00
Size: 100 ul
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