Serum proteins, also known as plasma or blood proteins, are a complex mix of proteins found in the plasma which serve multiple different functions including the transport of lipids, hormones, vitamins and metals through the circulatory system and the regulation of cellular activity, blood clotting and immune system function.
Analysis of serum proteins can provide an excellent source of biomarkers for a variety of conditions including cancers, cardiac infractions, HIV and other infectious diseases. Of the vast array of proteins found in serum, some are specific to blood whilst others are secreted into blood from tissues and organs. These tissue leakage factors reveal information about the tissue from which they originate and are therefore of great potential importance as disease biomarkers.
Fitzgerald Industries supplies a wide range of native and recombinant serum proteins and their antibodies ideally suited to research and diagnostic use. Our extensive catalog of serum proteins includes the most commonly measured plasma components including:
Prealbumin is a thyroid hormone-binding protein which transports thyroxine from the bloodstream to the brain. This native human Prealbumin protein has shown excellent results in ELISA, SDS-PAGE and Western blotting
Alpha 1 antitrypsin protein
Alpha 1 antitrypsin is a serine protease inhibitor which neutralizes trypsin that has leaked from the digestive system. It is elevated in inflammatory conditions, malignancies and liver disease. This Alpha 1 antitrypsin protein is purified directly from human plasma, while this recombinant Alpha 1 antichymotrypsin (His tag) conjugate is 95% pure and is an excellent control in immunoassays.
Alpha-fetoprotein (AFP protein)
AFP is the most abundant plasma protein found in the human fetus. Plasma levels decrease rapidly after birth but begin decreasing prenatally starting at the end of the first trimester. It is commonly used as a biomarker for monitoring the health of the fetus although it can also function as a tumor marker in adults. This AFP protein is purified from human cord serum and has shown good results in ELISA assays.
Alpha 2 Macroglobulin protein
A2M is a multifunctional protein which promotes growth of mammalian cells in culture, stimulates the regeneration of lymphocytes in irradiated mice, possesses a transport function for zinc and is a proteinase inhibitor that controls the clotting and fibrinolytic system. This Alpha 2 Macroglobulin protein is >96% pure and sourced from human serum.
Gamma globulin protein
Gamma globulins are a class of globulins which includes immunoglobulins. Gamma globulin injections have been shown to temporarily boost a patient's immunity against disease. Fitzgerald Industries offers native Human gamma Globulin protein, Bovine gamma Globulin protein and Pig gamma Globulin proteins.
beta 2 microglobulin protein
beta 2 microglobulin (or B2M) is a component of MHC class I molecules, which are present on all nucleated cells are vital for identifying foreign antigens to the immune system. This beta 2 Microglobulin protein is >95% pure and has been purified from the urine of patients with chronic renal tubular proteinuria. This less pure option of beta 2 Microglobulin is >60% pure.
In blood plasma, haptoglobin binds free hemoglobin released from erythrocytes with high affinity and thereby inhibits its oxidative activity. Haptoglobin level is used to determine whether or not hematology needs to be consulted for hemolytic anemia. This Haptoglobin protein is >98% pure and purified from Human plasma.
C-reactive protein (CRP protein)
Levels of C-reactive protein or CRP in the blood rise in response to inflammation, it binds phosphocholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system. This native CRP protein is highly purified from human pleural and ascites fluids ideal for use as an assay control.
Transferrin is a plasma protein that transports iron through the blood to the liver, spleen and bone marrow. Low transferrin can impair hemoglobin production and so lead to anemia. This native Transferrin protein has shown excellent results in ELISA and Western Blotting,
Prothrombin is a coagulation factor which is proteolytically cleaved to form thrombin in the coagulation cascade, which ultimately results in the reduction of blood loss. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. This native Thrombin protein is >95% pure from human plasma while this alpha Thrombin protein can be useful in clotting assays.
Browse our full list of proteins on our website.