Prothrombin precursor antibody (10R-8454)

Mouse monoclonal Prothrombin precursor antibody

Synonyms Monoclonal Prothrombin precursor antibody, Anti-Prothrombin precursor antibody, F2 antibody, coagulation factor II (thrombin) antibody, Cf2 antibody, Cf-2 antibody, coagulation factor 2 antibody, coagulation factor 2 (thrombin) antibody, coagulation factor II antibody, F2_BB antibody, FII antibody, Prothrombin antibody, prothrombin B-chain antibody, prothrombin precursor antibody, PT antibody, RP23-176N9.4 antibody, RPRGL2 antibody, serine protease antibody, silk fibroin 2 antibody, THPH1 antibody, thrombin antibody, thrombin B chain variant 1 antibody, vitamin K dependent serine protease antibody
Cross Reactivity Human
Applications ELISA, WB
Immunogen Prothrombin precursor antibody was raised in Mouse using a protein purified from Human plasma as the immunogen

Images

Western Blot analysis using Prothrombin precursor antibody (10R-8454)

Specifications

Host Mouse
Clone 28H5
Isotype IgG2b kappa
Method of Purification Prothrombin precursor antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:1000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Prothrombin precursor is synthesized in liver as a precursor of prothrombin containing a signal sequence and a propeptide domain at the N-terminus. Before its secretion into plasma, this precursor undergoes several posttranslational modifications, including removal of signal sequence and propeptide domains, glycosylation, and gamma-glutamyl-carboxylation reaction. Prothrombin, cleaved by the prothrombinase enzyme complex that consists of serine protease factor Xa, cofactor Va, phospholipids and calcium, is converted to thrombin which converts fibrinogen into fibrin which in turn strengthens a protective clot. Activation of prothrombin is crucial in physiological and pathological coagulation. Various rare diseases involving prothrombin (e.g. hypoprothrombinemia) have been described.

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Images

  • Western Blot analysis using Prothrombin precursor antibody (10R-8454) |

Availability: In stock

Price: $295.00
Size: 100 ul
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