Prox 1 antibody (70R-PR039)

Rabbit polyclonal Prox 1 antibody

Synonyms Polyclonal Prox 1 antibody, Anti-Prox 1 antibody, Prox 1, Prox 1, Prospero related homeobox 1 antibody, Prox -1 antibody, Prospero homeobox protein 1 antibody, Homeobox prospero like protein PROX1 antibody, Prox -1, Prox 1 antibody, Prox-1 antibody, Homeobox prospero like protein antibody, Prospero related homeobox 1 antibody
Specificity This antibody will detect Prox-1 in the nucleus of lymphatic endothelial cells by immunostaining, and human Prox 1 by western blot.
Cross Reactivity Equal reactivity with Human, Mouse, and Rat
Species Human
Applications IF, IHC-P, WB
Immunogen Prox 1 antibody was raised in rabbit using recombinant human C-terminal part of Prox-1 (homeo domain and prospero domain) as the immunogen

Specifications

Host Rabbit
Isotype IgG
Method of Purification Protein A chromatography
Form & Buffer IgG fraction supplied lyophilizedfrom PBS, pH 7.4 with no preservative.

Usage & Assay Information

Usage Recommendations WB: 1-5ug/ml. For other applications, optimal conditions should be determined by end-user

Storage & Safety

Storage Store lyophilized antibody at -20 deg C. Following reconstitution store at 4 deg C in the short-term. For longer term storage aliquot and store at -20 deg C or -70 deg C. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Prox-1 is a homeobox gene and acts as a master switch for lymphatic endothelial phenotype. Expression of Prox-1 in blood endothelial cells induces expression of other lymphatic marker genes. Together with Podoplanin, Prox-1 can be used to reliably distinguish lympathic vessels from blood vessels. Prox-1 is expressed in CNS, eye, pancreas, liver and heart, and it is one of the most specific and reliable markers for lymphatic endothelial cells.

References
Add a Paper

Rishikesh M. Kulkarni, James M. Greenberg, Ann L. Akeson

NFATc1 regulates lymphatic endothelial development

Mechanisms of Development

Volume: 126 Issue: 5-6 Page: 350-365 DOI: 10.1016/j.mod.2009.02.003

Rishikesh M. Kulkarnia, Amanda Hermana, Machiko Ikegamia, James M. Greenberga, Ann L. Akeson

Lymphatic ontogeny and effect of hypoplasia in developing lung

Mechanisms of Development

Volume: 128 Issue: 1-2 Page: 29-40 DOI: 10.1016/j.mod.2010.09.003

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Availability: In stock

Price: $397.00
Size: 200 ug
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