PSA/ACT complex protein (30-AP21)

Purified native Human PSA/ACT complex protein

Synonyms PSA-ACT complex protein, Prostate Specific Antigen/1-antichymotrypsin complex protein
Species Human
Protein Type Native
Applications User optimized

Specifications

Source Human plasma and seminal fluid
Purity > 96% pure
Molecular Weight 81 kDa
Form & Buffer 50mM PBS, pH 7.5, with 0.09% NaN3.

Storage & Safety

Storage Aliquot and store at -20 deg C. Avoid repeated freeze/thaw cycles
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

General Information

Biological Significance Prostate Specific Antigen (PSA), a glycoprotein of the glandular kallikrein family, is a serine protease with hymotrypsin-like enzymatic activity, is monitored as increased levels can indicate prostatic neoplasia. PSA released into circulation is present as unbound, free PSA (fPSA) or bound to serum protease inhibitors, such as a1-antichymotrypsin (ACT) and a2-macroglobulin (A2M). Research indicates that immunoassays for serum levels of PSA alone cannot be relied on to distinguish prostate cancer from benign prostatic hyperplasia (BPH). Serum levels of PSA-ACT complex are reportedly higher in patients with prostate cancer than in those with BPH. As such, measuring the ratio of PSA-ACT to fPSA in patient samples is proving valuable in the differential diagnosis os prostate cancer.

References
Add a Paper

Pavel Damborský, Narayanan Madaboosi, Virginia Chu, João P. Conde, Jaroslav Katrlík

Surface plasmon resonance application in prostate cancer biomarker research

Chemical Papers

Volume: 69 Issue: 1 Page: 143–149 DOI: 10.1515/chempap-2015-0053

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Availability: In stock

Price: $400.00
Size: 50 ug
OR
Shipping
View Our Distributors