PTRH2 protein (His tag) (80R-1591)
Purified recombinant Human PTRH2 protein
|Synonyms||PTRH2, PTRH-2 protein, PTRH-2, Peptidyl-tRNA hydrolase 2 protein, BIT1 protein, CGI-147 protein, PTRH 2 protein, PTRH 2, PTH2 protein, Bcl-2 inhibitor of transcription 1|
Coomassie Blue stained SDS-PAGE of PTRH2 protein (His tag) (80R-1591)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||64-179 amino acids: MGSSHHHHHH SSGLVPRGSH MEYKMILVVR NDLKMGKGKV AAQCSHAAVS AYKQIQRRNP EMLKQWEYCG QPKVVVKAPD EETLIALLAH AKMLGLTVSL IQDAGRTQIA PGSQTVLGIG PGPADLIDKV TGHLKLY|
|Purity||> 95% pure|
|Molecular Weight||14.9 kDa (137aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris buffer, pH 8.0, containing 10% glycerol and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||PTRH2 (peptidyl-tRNA hydrolase 2), also known as BIT1, is a mitochondrial protein. During apoptosis, PTRH2 is released from the mitochondria to the cytoplasm. Once in the cytoplasm, PTRH2 regulates the function of two transcriptional regulators, TLE5 and TLE1, thereby promoting caspase-independent cell death. The natural substrate for PTRH2 may be petidyl-tRNAs which drop off the ribosome during protein synthesis. Recombinant human PTRH2 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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