RAF1 antibody (Ser642) (70R-15055)

Rabbit polyclonal RAF1 antibody (Ser642)

Synonyms Polyclonal RAF1 antibody, Anti-RAF1 antibody, RAF 1 antibody, RAF-1 antibody, RAF1, cRaf antibody, c Raf antibody, Craf 1 transforming gene antibody, cRaf antibody, cRaf1 transforming gene antibody, Murine sarcoma 3611 oncogene 1 antibody, NS5 antibody, Oncogene RAF1 antibody, OTTHUMP00000160218 antibody, OTTHUMP00000207813 antibody, OTTHUMP00000209389 antibody, Proto-oncogene c-RAF antibody, Raf proto oncogene serine threonine protein kinase antibody, Raf proto oncogene serine/threonine protein kinase antibody, RAF proto-oncogene serine/threonine-protein kinase antibody, RAF-1 antibody, RAF1 antibody, Sarcoma 3611 oncogene antibody, v raf 1 murine leukemia viral oncogene homolog 1 antibody, vraf1 murine leukemia viral oncogene homolog 1 antibody, vRaf1 murine leukemia viral oncogene homologue 1 antibody
Applications WB

Specifications

Host Rabbit
Method of Purification RAF1 antibody was purified by affinity chromatography
Form & Buffer Supplied in liquid form in 10 mM HEPES buffer (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:1000

General Information

Biological Significance RAF1 is a serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'.

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Availability: In stock

Price: $335.00
Size: 100 ul
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