RAG2 antibody (10R-1893)
Mouse monoclonal RAG2 antibody
|Synonyms||Monoclonal RAG2 antibody, Anti-RAG2 antibody, RAG-2, RAG 2 antibody, RAG 2 antibody, RAG-2 antibody, RAG 2, RAG2, RAG-2 antibody|
|Immunogen||RAG2 antibody was raised in Mouse using a purified recombinant fragment of human RAG2(350-527aa) expressed in E. coli as the immunogen.|
Western Blot analysis using RAG2 antibody (10R-1893)
Western Blot showing RAG2 antibody used against RAG2 (AA: 350-527)-hIgGFc transfected HEK293 (1)cell lysate.
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||RAG2 is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA.|
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