RAMP3 protein (His tag) (80R-2674)
Purified recombinant RAMP3 protein (His tag)
|Synonyms||Receptor activity modifying protein 3 protein, Receptor (calcitonin) activity modifying protein 3 protein, RAMP3, RAMP 3, RAMP-3, RAMP 3 protein, RAMP-3 protein|
SDS-PAGE analysis of RAMP3 protein (His tag) (80R-2674)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||24-118 aa: MGSSHHHHHH SSGLVPRGSH MRAGGCNETG MLERLPLCGK AFADMMGKVD VWKWCNLSEF IVYYESFTNC TEMEANVVGC YWPNPLAQGF ITGIHRQFFS NCTVDRVHLE DPPDEV|
|Purity||> 90% pure|
|Molecular Weight||13.0 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl|
Storage & Safety
|Storage||Can be stored at 4 deg C for short terms (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles|
|Biological Significance||RAMP3, also known as receptor activity modifying protein 3, is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). It is required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. Recombinant human RAMP3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
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