Rat IL4 ELISA kit (55R-1615)

ELISA kit for the detection of Rat IL4 in the research laboratory

Synonyms Rat IL4 ELISA kit, Interleukin 4 ELISA kit
Applications ELISA
Assay Information Sensitivity: 7.8 pg/ml-500 pg/ml

Images

ELISA assay using Rat IL4 ELISA kit (55R-1615)

Graph showing ELISA absorbance curve (O.D.) of Rat IL4 (pg/ml)

Specifications

Form & Buffer This Kit contains: Lyophilized recombinant rat IL-4 standard: 10ng/tube

Storage & Safety

Storage Store at 4 deg C for short term storage (4 months) or -20 deg C for long term storage (8 months)

General Information

Biological Significance The function of IL4 is mediated by binding to receptors expressed on target cells. Receptors exist on freshly prepared B and T lymphocytes and macrophages, as well as on various cell lines including lymphoid cells, mast cell lines, a variety of other hematopoietic cell lines, fibroblasts and stromal cell lines. On T and B cells, receptors are present in low numbers (approximately 400), which are reported to be upregulated by IL2 and IL4. IL4 is produced by a particular subset of T helper cells, the TH2 cells. These cells tend to make a specific set of lymphokines including IL4, IL5, IL6, IL10, IL13 and GMCSF and fail to produce IL2, IFN gamma, and lymphotoxin (TNF beta). Apart from T cells, it has been shown that mast cells can produce IL4. IL4 exerts numerous effects on various hematopoietic cell types. On B cells, IL4 promotes immunological class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. It can promote survival, growth, and differentiation of both T and B lymphocytes, mast cells, and endothelial cells. In addition, IL4 can inhibit the production of TNF, IL1, and IL6 by macrophages.

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  • <div><font face=Calibri size=2>ELISA assay using Rat IL4 ELISA kit (55R-1615)</font></div>     | Graph showing ELISA absorbance curve (O.D.) of Rat IL4 (pg/ml)

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Price: $350.00
Size: 1 kit
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