RB antibody (10R-1797)
Mouse monoclonal RB antibody
|Synonyms||Monoclonal RB antibody, Anti-RB antibody|
|Immunogen||RB antibody was raised in Mouse using a purified recombinant fragment of human RB expressed in E. coli as the immunogen.|
Immunohistochemical staining using RB antibody (10R-1797)
Immunohistochemical staining of paraffin-embedded human normal esophagus (A) and stomach (B) tissue, showing nucleus localization using Rb antibody with DAB staining.
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, IHC: 1:200-1:1000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||The RB protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of RB at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene.|
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