RB antibody (10R-1797)

Mouse monoclonal RB antibody

Synonyms Monoclonal RB antibody, Anti-RB antibody
Cross Reactivity Human
Applications ELISA, IHC
Immunogen RB antibody was raised in Mouse using a purified recombinant fragment of human RB expressed in E. coli as the immunogen.

Images

Immunohistochemical staining using RB antibody (10R-1797)

Immunohistochemical staining of paraffin-embedded human normal esophagus (A) and stomach (B) tissue, showing nucleus localization using Rb antibody with DAB staining.

Specifications

Host Mouse
Clone 7E4B8
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IHC: 1:200-1:1000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance The RB protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of RB at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Images

  • Immunohistochemical staining using RB antibody (10R-1797) | Immunohistochemical staining of paraffin-embedded human normal esophagus (A) and stomach (B) tissue, showing nucleus localization using Rb antibody with DAB staining.

Availability: In stock

Price: $195.00
Size: 100 ul
OR
Shipping
View Our Distributors