Ret antibody (10R-2120)
Mouse monoclonal Ret antibody
|Synonyms||Monoclonal Ret antibody, Anti-Ret antibody, c-Ret antibody, Anti Ret antibody, Ret proto-oncogene antibody, c-Ret antibody, Ret antibody, Ret proto-oncogene antibody|
|Immunogen||Ret antibody was raised in Mouse using a purified recombinant fragment of Ret (aa896-1063) expressed in E. coli as the immunogen.|
Western Blot analysis using Ret antibody (10R-2120)
Western Blot showing RET antibody used against truncated RET recombinant protein (1) and RET (aa658-1063)-hIgGFc transfected CHO-K1 cell lysate (2).
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Ret is a receptor tyrosine kinase that functions as a multicompetent receptor complex in conjunction with other membrane-bound ligand-binding GDNF family receptors. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung’s disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.|
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